Proteolysis: Adaptor, Adaptor, Catch Me a Catch
نویسندگان
چکیده
منابع مشابه
Proteolysis: Adaptor, Adaptor, Catch Me a Catch
The ClpXP protease of bacteria can degrade a wide variety of proteins while maintaining remarkable substrate selectivity. New work in Escherichia coli implicates adaptor proteins in enhancing substrate selectivity and regulating the flow of substrates to cellular proteases.
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I nfectious diseases are one of the main causes of death worldwide. Several of the most deadly bacterial pathogens, such as Salmonella enterica and Listeria monocytogenes, cause disease by multiplying inside human cells. The human body is constantly patrolled by immune cells, and contains lots of antibodies and other molecules that can target and kill microbes, but the environment inside host c...
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Regulated protein degradation is essential. The timed destruction of crucial proteins by the ClpXP protease drives cell-cycle progression in the bacterium Caulobacter crescentus. Although ClpXP is active alone, additional factors are inexplicably required for cell-cycle-dependent proteolysis. Here, we show that these factors constitute an adaptor hierarchy wherein different substrates are destr...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2004
ISSN: 0960-9822
DOI: 10.1016/j.cub.2004.10.015